Cholicamideβ
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis[1].
Product Specifications
CAS Number
3036578-71-6
UNSPSC
12352211
Target
Apoptosis; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cholicamideβ.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12C[C@@H]([C@@]3([C@H](CC[C@]3([C@]1([H])CC[C@@]4(C[C@@H](CC[C@]24C)O)[H])[H])[C@@H](CCC(NCCCCCCCNC(CC[C@H]([C@@H]5[C@@]6(C)[C@@H](O)C[C@@]7([H])[C@@](CC[C@@]8(C[C@@H](CC[C@@]87C)O)[H])([C@@]6(CC5)[H])[H])C)=O)=O)C)C)O
Molecular Formula
C55H94N2O6
Molecular Weight
879.34
References & Citations
[1]Zhuo SH, et al. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile. J Med Chem. 2023 Sep 7.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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