TRK-IN-24
Product Specifications
UNSPSC Description
TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA, TRKC, TRKAG595R, TRKAG667C and TRKAF589L IC50s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1G595R and BaF3-CD74-NTRK1G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC50 of 1.43-47.56 nM[1].
Target Antigen
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-24.html
Solubility
10 mM in DMSO
Smiles
CC(C(C#CC1=CN=C2C=CC3=NN21)=CC(OCCCCCCCNC3=O)=C4)=C4C(NC5=CC(C6CC6)=CC(CN7CCN(CC7)C)=C5)=O
Molecular Weight
659.82
References & Citations
[1]Wang Z, et al. Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J Med Chem. 2023 Sep 7.. .
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156086/TRK-IN-24-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156086/
Clinical Information
No Development Reported
CAS Number
2937544-01-7
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