LP23
LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC50: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg) [1].
Product Specifications
CAS Number
3008239-25-3
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lp23.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NCC1=CC(CSC2=NN=C(COC3=C(C)C(C4=CC=CC=C4)=CC=C3)O2)=CC=C1)CO)O
Molecular Formula
C27H27N3O5S
Molecular Weight
505.59
References & Citations
[1]Liu J, et al. Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine) -Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J Med Chem. 2023 Sep 6.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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