LL-K9-3

LL-K9-3 is a potent small-molecule degrader of CDK9-cyclin T1. LL-K9-3 has anti-proliferative and pro-apoptotic activities and suppresses downstream signaling of CDK9 and AR. Moreover, LL-K9-3 inhibits AR and Myc-driven oncogenic transcriptional programs[1].

Product Specifications

CAS Number

[2809353-52-2]

UNSPSC

12352005

Target

Apoptosis; CDK; c-Myc; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ll-k9-3.html

Purity

99.2

Solubility

10 mM in DMSO

Smiles

O=S(CCNC(CO[C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)(N2CCC(CC2)C(NC3=NC=C(SCC4=NC=C(C(C)(C)C)O4)S3)=O)=O

Molecular Formula

C31H49N5O6S3

Molecular Weight

683.95

References & Citations

[1]Li J, et al. Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer. J Med Chem. 2022 Aug 25;65 (16) :11034-11057.