LL-K9-3
LL-K9-3 is a potent small-molecule degrader of CDK9-cyclin T1. LL-K9-3 has anti-proliferative and pro-apoptotic activities and suppresses downstream signaling of CDK9 and AR. Moreover, LL-K9-3 inhibits AR and Myc-driven oncogenic transcriptional programs[1].
Product Specifications
CAS Number
2809353-52-2
UNSPSC
12352005
Target
Apoptosis; CDK; c-Myc; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ll-k9-3.html
Purity
99.2
Solubility
10 mM in DMSO
Smiles
O=S(CCNC(CO[C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)(N2CCC(CC2)C(NC3=NC=C(SCC4=NC=C(C(C)(C)C)O4)S3)=O)=O
Molecular Formula
C31H49N5O6S3
Molecular Weight
683.95
References & Citations
[1]Li J, et al. Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer. J Med Chem. 2022 Aug 25;65 (16) :11034-11057.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
031933-PE 200 µL
AOAH, ID (AOAH, Acyloxyacyl hydrolase, Acyloxyacyl hydrolase small subunit, Acyloxyacyl hydrolase large subunit) (PE) discontinued
Sign In for Pricing
View Details MBS1446534-01 0.02 mg (E-Coli)
Recombinant Francisella tularensis subsp. holarctica Trigger factor (tig)
Sign In for Pricing
View Details MBS1446534-02 0.02 mg (Yeast)
Recombinant Francisella tularensis subsp. holarctica Trigger factor (tig)
Sign In for Pricing
View Details MBS1446534-03 0.1 mg (E-Coli)
Recombinant Francisella tularensis subsp. holarctica Trigger factor (tig)
Sign In for Pricing
View Details