CDK9-IN-28
PROTAC CDK9/CycT1 Degrader-1 (compounds 10) is a potent inhibitor of CDK9. PROTAC CDK9/CycT1 Degrader-1 can be used as a PROTAC target protein ligand for PROTAC synthesis. PROTAC CDK9/CycT1 Degrader-1 shows strong anti-proliferative activity in solid tumors[1].
Product Specifications
CAS Number
[3020773-81-0]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-cdk9-cyct1-degrader-1.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C1=CN=C(O1)CSC2=CN=C(S2)NC(C3CCN(CC3)CCCCCOC4=C5C(OC(C=C5C)=O)=CC(O)=C4)=O)C
Molecular Formula
C32H40N4O6S2
Molecular Weight
640.81
References & Citations
[1]Zeng Y, et al. Degradation of Cyclin-Dependent Kinase 9/Cyclin T1 by Optimized Microtubule-Associated Protein 1 Light Chain 3 Beta-Recruiting Coumarin Analogs. J Med Chem. 2023 Sep 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Curated Selection
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