Nrf2 activator-9
Product Specifications
UNSPSC Description
Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis[1].
Target Antigen
Apoptosis; Keap1-Nrf2
Type
Reference compound
Related Pathways
Apoptosis;NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-9.html
Solubility
10 mM in DMSO
Smiles
OC1=CC(/C=C/C(N2CCN(CC2)CC3=NOC(CC4=CNC5=CC=CC=C54)=N3)=O)=CC=C1OC
Molecular Weight
473.52
References & Citations
[1]Zhang J, et al. Discovery of marine phidianidine-based Nrf2 activators and their potential against oxLDL- and HG-induced injury in HUVECs. Bioorg Med Chem Lett. 2023 Sep 7;95:129468.. .
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156081/Nrf2-activator-9-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156081/
Clinical Information
No Development Reported
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