EGFR-IN-88
EGFR-IN-88 (Compound 4i) is an EGFR inhibitor (IC50: 87 nM) . EGFR-IN-88 shows cytotoxicity against A549 cell with an IC50 of 3.902 μM. EGFR-IN-88 can induce cell apoptosis[1].
Product Specifications
CAS Number
2944452-34-8
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-88.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(Cl)C=C1Cl)CSC2=NN=C(C3=CC=C4N=C(CC)C(CC)=NC4=C3)O2
Molecular Formula
C22H18Cl2N4O2S
Molecular Weight
473.37
References & Citations
[1]Ali SH, et al. Design, synthesis, and molecular docking studies of novel quinoxaline derivatives as anticancer agents. Chem Biol Drug Des. 2023 Aug;102 (2) :303-315.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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