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BChE-IN-19

BChE-IN-19 (Compound 7b) is a para-substituted derivative of indone (7b) with inhibitory activity of butyryl cholinesterase (BChE) (IC50=0.04 μM) . BChE-IN-19 improves cholinergic scheduling in the nervous system. BChE-IN-19 can be used against Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bche-in-19.html

Solubility

10 mM in DMSO

Smiles

O=C1C(CC2=CC=C(OCCCN3CCOCC3)C=C2)CC4=C1C=C(OC)C(OC)=C4

Molecular Formula

C25H31NO5

Molecular Weight

425.52

References & Citations

[1]Etemadi A, et al. Design, Synthesis, and Biological Evaluation of Novel Indanone Derivatives as Cholinesterase Inhibitors for Potential Use in Alzheimer's Disease. Chem Biodivers. 2023 Aug;20 (8) :e202300075.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BChE

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