PSEN1-IN-1
Product Specifications
UNSPSC Description
PSEN1-IN-1 (Compound (+)-13b) is a PSEN1 inhibitor. PSEN1-IN-1 inhibits PSEN1-APH1A and PSEN1-APH1B complex with IC50s of 19 and 5.5 nM. PSEN1-IN-1 can be used for Alzheimer's disease research[1].
Target Antigen
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling;Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/psen1-in-1.html
Solubility
10 mM in DMSO
Smiles
FC(F)(C1=CC=C([C@H]([C@@H]2CC3)N(S(C4=CC=C(Cl)C=C4)(=O)=O)[C@@H]3C[C@@H]2O)C=C1)F
Molecular Weight
445.88
References & Citations
[1]Narlawar R, et al. Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors. Eur J Med Chem. 2023 Nov 15;260:115725.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156011/PSEN1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156011/
Clinical Information
No Development Reported
Curated Selection
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