FD2157
Product Specifications
UNSPSC Description
FD2157 is a photosensitive PI3K inhibitor, with IC50s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light[1].
Target Antigen
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fd2157.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC(OC)=C(OC)C=C1[N+]([O-])=O)N(N=C2)C(C2=C3)=NC=C3C4=CN=C(Cl)C(NS(=O)(C5=CC=CC=C5)=O)=C4
Molecular Weight
625.01
References & Citations
[1]Yang C, et al. Discovery of a photosensitizing PI3K inhibitor for tumor therapy: Design, synthesis and in vitro biological evaluation. Bioorg Med Chem Lett. 2023 Oct 1;94:129459.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155996/FD2157-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155996/
Clinical Information
No Development Reported
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