PRO-905

Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) [1].

Product Specifications

CAS Number

[2762209-68-5]

Product Name Alternative

MK-905

UNSPSC

12352005

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pro-905.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=S)=C3N=C2)O[C@@H]1COP(N[C@H](C(OC(C)C)=O)C)(OC4=CC=CC=C4)=O

Molecular Formula

C22H29N6O8PS

Molecular Weight

568.54

References & Citations

[1]Lemberg KM, et al. Pro-905, a novel purine antimetabolite, combines with glutamine amidotransferase inhibition to suppress growth of malignant peripheral nerve sheath tumor. Mol Cancer Ther. 2023 Aug 24:MCT-23-0258.