RUNX-IN-2

RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity[1].

Product Specifications

CAS Number

[2893777-88-1]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/runx-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC(NC(CCNC(CCCC2=CC=C(N(CCCl)CCCl)C=C2)=O)=O)=CN1C)NC3=CN(C)C(C(NC4=CN(C)C(C(NC5=CN(C)C(C(NCCCC(NC6=CN(C)C(C(NC7=CN(C)C(C(NC8=CN(C)C(C(NC9=CN(C)C(C(NCCCN(C)C)=O)=C9)=O)=C8)=O)=C7)=O)=C6)=O)=O)=N5)=O)=C4)=O)=N3

Molecular Formula

C71H88Cl2N24O11

Molecular Weight

1524.52

References & Citations

[1]Hirose Y, et al. Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells. J Med Chem. 2023 Sep 14;66 (17) :12059-12068.