EGFR-IN-83
EGFR-IN-83 (Compound 9) is an EGFR inhibitor (IC50: 2.53 nM) . EGFR-IN-83 has antiproliferative activity against MCF-7 and MDA-MB-231 cells, with IC50 of 2.50 μM and 1.96 μM. EGFR-IN-83 can induce cell apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-83.html
Solubility
10 mM in DMSO
Smiles
OCC1=CC=C(NC2=CC3=NC=NC(NC4=CC=CC(C(F)(F)F)=C4)=C3C=C2)C=C1
Molecular Formula
C22H17F3N4O
Molecular Weight
410.39
References & Citations
[1]Hossam Nada, et al. Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer-Design, Synthesis, and In Vitro Evaluation. ACS Omega 2023, 8, 35, 31784-31800.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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