CB1R/AMPK modulator 1
CB1R/AMPK modulator 1 (Compound 38-S) is an orally active CB1R/AMPK modulator, with an Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK. CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity[1].
Product Specifications
CAS Number
2711012-08-5
UNSPSC
12352005
Target
AMPK; Cannabinoid Receptor
Type
Reference compound
Related Pathways
Epigenetics; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cb1r-ampk-modulator-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C=C1)C2=NN(C[C@@H]2C3=CC=CC=C3)C(/N=C(N)/NC(C)=O)=N/S(=O)(C4=CC=C(C=C4)Cl)=O
Molecular Formula
C25H22Cl2N6O3S
Molecular Weight
557.45
References & Citations
[1]Dvorácskó S, et al. Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders. J Med Chem. 2023 Aug 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
