SH491
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC50: 11.8 nM) . SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9) [1].
Product Specifications
CAS Number
2975285-28-8
UNSPSC
12352005
Target
Cathepsin; MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sh491.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@]([H])(C(C)(C)C3=C(C2)C=NC(C)=N3)CC[C@@]4([C@@]1(C[C@H]([C@]5([C@]4(CC[C@@H]5C(CC/C=C(C)\C)=C)C)[H])O)[H])C
Molecular Formula
C33H50N2O
Molecular Weight
490.76
References & Citations
[1]Wang SJ, et al. Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20 (S) -Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents. J Med Chem. 2023 Aug 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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