5-Hydroxydecanoic acid

5-Hydroxydecanoic acid (5-HD) is a KATP channel antagonist, which has the effect of blocking the K KATP channel only during ischaemia by competing with the ATP binding site and does not affect pancreatic KATP channels[1].

Product Specifications

CAS Number

[624-00-0]

UNSPSC

12352211

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-hydroxydecanoic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(CCCC(CCCCC)O)O

Molecular Formula

C10H20O3

Molecular Weight

188.26

References & Citations

[1]J A Auchampach, et al. Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate. Cardiovasc Res. 1992 Nov;26 (11) :1054-62.