Phen-DC3
Product Specifications
UNSPSC Description
Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Phen-DC3.html
Solubility
DMSO : ≥ 34 mg/mL
Smiles
C[N+]1=C2C=CC=CC2=CC(NC(C3=CC=C4C=CC5=CC=C(C(NC6=C[N+](C)=C7C=CC=CC7=C6)=O)N=C5C4=N3)=O)=C1
Molecular Weight
550.61
References & Citations
[1]Bharti SK, et al. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem. 2013 Sep 27; 288(39):28217-29.J Phys Chem B. 2023 Jun 25.|Nucleic Acids Res. 2024 Feb 10:gkae073.|Patent. US20210188889A1.|Cell Death Dis. 2021 Oct 25;12(11):999.|iScience. 9 October 2022, 105312.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15594/Phen-DC3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15594/
Clinical Information
No Development Reported
CAS Number
942936-75-6
Curated Selection
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