Phen-DC3
Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
Product Specifications
CAS Number
942936-75-6
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Phen-DC3.html
Solubility
DMSO : ≥ 34 mg/mL
Smiles
C[N+]1=C2C=CC=CC2=CC(NC(C3=CC=C4C=CC5=CC=C(C(NC6=C[N+](C)=C7C=CC=CC7=C6)=O)N=C5C4=N3)=O)=C1
Molecular Formula
C34H26N6O2
Molecular Weight
550.61
References & Citations
[1]Bharti SK, et al. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem. 2013 Sep 27; 288 (39) :28217-29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Phys Chem B. 2023 Jul 6;127 (26) :5859-5868.|Nucleic Acids Res. 2024 Mar 21;52 (5) :2142-2156.|Patent. US20210188889A1.|Cell Death Dis. 2021 Oct 25;12 (11) :999.|Int J Biol Macromol. 2025 Jan 9:139582.|Int J Biol Macromol. 2025 Jun 20;319 (Pt 1) :145405.|iScience. 2022 Oct 9;25 (11) :105312.
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