M4K2163 (dihydrochloride)

M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG) [1][2].

Product Specifications

CAS Number

[2863635-04-3]

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m4k2163-dihydrochloride.html

Purity

98.30

Solubility

10 mM in DMSO

Smiles

FC1=C(C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC)OC.Cl.Cl

Molecular Formula

C24H28Cl2FN3O2

Molecular Weight

480.40

References & Citations

[1]Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63 (17) :10061-10085.|[2]Rooney L, et al. Recent Advances in ALK2 Inhibitors. ACS Omega. 2021 Aug 6;6 (32) :20729-20734.