M4K2163 (dihydrochloride)
M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG) [1][2].
Product Specifications
CAS Number
[2863635-04-3]
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m4k2163-dihydrochloride.html
Purity
98.30
Solubility
10 mM in DMSO
Smiles
FC1=C(C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC)OC.Cl.Cl
Molecular Formula
C24H28Cl2FN3O2
Molecular Weight
480.40
References & Citations
[1]Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63 (17) :10061-10085.|[2]Rooney L, et al. Recent Advances in ALK2 Inhibitors. ACS Omega. 2021 Aug 6;6 (32) :20729-20734.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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