IV-275
IV-275 is an inhibitor of both BRG1 and BRM bromodomains. IV-275 increases the extent of DNA damage induced by Temozolomide and Bleomycin (HY-108345). IV-275 inhibits the invasiveness of GBM cells. IV-275 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iv-275.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(N2[C@H]3CN([C@@H](C2)C3)C(OC4=CC(F)=C(C=C4)F)=O)C=C1
Molecular Formula
C19H18F2N2O3
Molecular Weight
360.35
References & Citations
[1]Yang C, et al. Next-generation bromodomain inhibitors of the SWI/SNF complex enhance DNA damage and cell death in glioblastoma. J Cell Mol Med. 2023 Sep;27 (18) :2770-2781.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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