Lepadin H
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].
Product Specifications
CAS Number
412328-25-7
UNSPSC
12352005
Target
Ferroptosis
Type
Natural Products
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/lepadin-h.html
Solubility
10 mM in DMSO
Smiles
CCC[C@@H](O)CCCC[C@@H]1[C@@]2([H])[C@](CCC1)([H])N[C@H]([C@@H](C2)OC(/C=C/C=C/CCC)=O)C
Molecular Formula
C26H45NO3
Molecular Weight
419.64
References & Citations
[1]Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66 (16) :11201-11215.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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