Lepadin E
Product Specifications
UNSPSC Description
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect[1].
Target Antigen
Ferroptosis; Glutathione Peroxidase; MDM-2/p53
Type
Natural Products
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/lepadin-e.html
Solubility
10 mM in DMSO
Smiles
CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O
Molecular Weight
421.66
References & Citations
[1]Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155851/Lepadin-E-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155851/
Clinical Information
No Development Reported
CAS Number
444914-19-6
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
TM-021Z-55 150 µg
Anti-Excision Repair Cross Complement (ERCC2). IgG fraction (Monoclonal)
Ask
View Details 
MBS1220595-01 0.02 mg (E-Coli)
Recombinant Natranaerobius thermophilus ATP synthase subunit delta (atpH)
Ask
View Details MBS1220595-02 0.1 mg (E-Coli)
Recombinant Natranaerobius thermophilus ATP synthase subunit delta (atpH)
Ask
View Details MBS1220595-03 0.02 mg (Yeast)
Recombinant Natranaerobius thermophilus ATP synthase subunit delta (atpH)
Ask
View Details