PKM2-IN-4
Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling[1].
Product Specifications
CAS Number
2996165-24-1
UNSPSC
12352005
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkm2-in-4.html
Solubility
10 mM in DMSO
Smiles
BrC1=C([Se][N+]2=C1C=C(C(OC)=O)C=C2)C3(CCCCC3)O.[Cl-]
Molecular Formula
C15H17BrClNO3Se
Molecular Weight
453.62
References & Citations
[1]Dimitrijevs P, et al. Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. Eur J Med Chem. 2023 Sep 5;257:115504.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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