Antileishmanial agent-21
Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1) . Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A) -resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM[1].
Product Specifications
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antileishmanial-agent-21.html
Solubility
10 mM in DMSO
Smiles
OC(C(OC)=C1)=CC=C1C(C2=C(C3=CC=CC=C3CC2)NC4=O)=C4C#N
Molecular Formula
C21H16N2O3
Molecular Weight
344.36
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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