Antileishmanial agent-21

Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1) . Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A) -resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-21.html

Solubility

10 mM in DMSO

Smiles

OC(C(OC)=C1)=CC=C1C(C2=C(C3=CC=CC=C3CC2)NC4=O)=C4C#N

Molecular Formula

C21H16N2O3

Molecular Weight

344.36

References & Citations

[1]Ibrahim TM, et al. Tetrahydrobenzo[h]quinoline derivatives as a novel chemotype for dual antileishmanial-antimalarial activity graced with antitubercular activity: Design, synthesis and biological evaluation. Eur J Med Chem. 2023 Sep 5;257:115534..