Tubulin polymerization-IN-46
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC50 of 10 nM[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-46.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC(OC)=C(OC)C(OC)=C2)[C@@H](C3=CC=C(OC)C(O)=C3)[C@@H]1C(C)=C
Molecular Formula
C22H25NO6
Molecular Weight
399.44
References & Citations
[1]Wang S, et al. Antiproliferative and Tubulin-Destabilising Effects of 3- (Prop-1-en-2-yl) azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells. Pharmaceuticals (Basel) . 2023 Jul 13;16 (7) :1000..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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