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Auristatin E (GMP)

Product Specifications

UNSPSC Description

Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor[1].

Target Antigen

ADC Cytotoxin; Microtubule/Tubulin

Type

GMP Small Molecules

Related Pathways

Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/auristatin-e-gmp.html

Solubility

10 mM in DMSO

Smiles

CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O

Molecular Weight

732.01

References & Citations

[1]Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-15582G/Auristatin-E-GMP-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15582G/

Clinical Information

No Development Reported

CAS Number

160800-57-7

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