Auristatin E (GMP)
Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor[1].
Product Specifications
CAS Number
[160800-57-7]
UNSPSC
12352005
Hazard Statement
H341-H361-H372
Target
ADC Payload; Microtubule/Tubulin
Type
GMP Small Molecules
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/auristatin-e-gmp.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O
Molecular Formula
C40H69N5O7
Molecular Weight
732.01
Precautions
P260-P264-P270-P280-P405-P501
References & Citations
[1]Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102 (4) :1458-65.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Curated Selection
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