Anti-inflammatory agent 54
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].
Product Specifications
CAS Number
2924156-46-5
UNSPSC
12352005
Target
Interleukin Related; NF-κB; NO Synthase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-54.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C/C1=CC=CO1)NCCN2C3=CC=C(OC)C=C3OC2=O
Molecular Formula
C17H16N2O5
Molecular Weight
328.32
References & Citations
[1]Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86 (8) :1950-1959..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD63 Recombinant Monoclonal Mouse Antibody (2304.63), CF®583R Conjugate - Biotium Choice
Human Clusterin Recombinant Rabbit monoclonal Antibody
