Anti-inflammatory agent 54
Product Specifications
UNSPSC Description
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].
Target Antigen
Interleukin Related; NF-κB; NO Synthase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-54.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C/C1=CC=CO1)NCCN2C3=CC=C(OC)C=C3OC2=O
Molecular Weight
328.32
References & Citations
[1]Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86(8):1950-1959..
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155820/Anti-inflammatory-agent-54-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155820/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
