BET-IN-17
BET-IN-17 (compound 16) is a pan-inhibitor of BET with pIC50s of 7.8 and 7.6 for BET BD1 and BET BD2, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-17.html
Solubility
10 mM in DMSO
Smiles
CN1C=CC2=C([C@H](C1=O)C)C=CC(CN3CCN(CC3)CC4=CC=C5[C@H](C(N(C=CC5=C4)C)=O)C)=C2
Molecular Formula
C30H36N4O2
Molecular Weight
484.63
References & Citations
[1]Bamborough P, et al. Design and Characterization of 1, 3-Dihydro-2 H-benzo [d] azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors[J]. ACS Medicinal Chemistry Letters, 2023.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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