DPP
Product Specifications
UNSPSC Description
DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand. DPP inhibit the JAK2-STAT3 pathway in breast cancer (BC) cells with antiproliferative activity, and activates caspase-3 and cleaved poly ADP-ribose polymerase to induces apoptosis. DPP promotes the maturation and antigen presentation of dendritic cells, and exhibits in vivo safety[1].
Target Antigen
Apoptosis; JAK; STAT
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/dpp.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=CC(/C=C/C(C=C2)=CC=C2OCC([O-][Pt+4]([Cl-])([Cl-])([NH3])([NH3])[O-]C(COC(C=C3)=CC=C3/C=C/C4=CC(OC)=CC(OC)=C4)=O)=O)=C1
Molecular Weight
926.70
References & Citations
[1]Cai L, et al. Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11351-11364.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155807/DPP-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155807/
Clinical Information
Phase 3
CAS Number
2668267-47-6
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