McMMAF (GMP)

McMMAF GMP is a GMP grade McMMAF (HY-15578) . McMMAF is a protective group (maleimidocaproyl) -conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC) . McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent[1][2].

Product Specifications

CAS Number

[863971-19-1]

Product Name Alternative

Maleimidocaproyl monomethylauristatin F (GMP)

UNSPSC

12352005

Hazard Statement

H300-H310-H330

Target

Drug-Linker Conjugates for ADC

Type

GMP Small Molecules

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mcmmaf-gmp.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@@]([H])(N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)C)[C@@H](C)CC)=O)OC)N[C@H](C(O)=O)CC3=CC=CC=C3

Molecular Formula

C49H76N6O11

Molecular Weight

925.16

Precautions

P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69 (6) :2358-2364.|[2]Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.