McMMAF (GMP)
McMMAF GMP is a GMP grade McMMAF. McMMAF is a protective group (maleimidocaproyl) -conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent[1][2].
Product Specifications
CAS Number
863971-19-1
Product Name Alternative
Maleimidocaproyl monomethylauristatin F (GMP)
UNSPSC
12352005
Hazard Statement
H300-H310-H330
Target
Drug-Linker Conjugates for ADC
Type
GMP Small Molecules
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcmmaf-gmp.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C49H76N6O11
Molecular Weight
925.16
Precautions
P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Frequently Asked Questions
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