HCA/VEGFR-2-IN-3
HCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-3 inhibits VEGFR-2 (IC50=358 nM), has high binding activity to hCAs with Ki of 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII), respectively. hCA/VEGFR-2-IN-3 has antiproliferative activity against VEGFR-2 overexpressing breast cancer cells[1].
Product Specifications
CAS Number
2971782-73-5
UNSPSC
12352005
Target
Carbonic Anhydrase; VEGFR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hca-vegfr-2-in-3.html
Solubility
10 mM in DMSO
Smiles
CC(N1CC(C(N/N=C2C(NC3=C\2C=C(OC)C=C3)=O)=O)CCC1)C(NC4=CC=C(S(=O)(N)=O)C=C4)=O
Molecular Formula
C24H28N6O6S
Molecular Weight
528.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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