Anti-inflammatory agent 50

Anti-inflammatory agent 50 (compound a1) is a Fusidic acid derivative with anti-inflammatory effects. Anti-inflammatory agent 50 inhibits inflammatory factor NO, IL-6 and TNF-α. Anti-inflammatory agent 50 alleviates acute lung injury by regulating inflammatory mediators and suppressing the MAPK, NF-κB and NLRP3 inflammasome signaling pathways[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

COX; NF-κB

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-50.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C\CC/C(C(OCC1=CN(C2=CC=CC=C2)N=N1)=O)=C3[C@@H](OC(C)=O)C[C@]4(C)[C@@]5(C)CC[C@@]6([H])[C@H](C)[C@H](O)CC[C@]6(C)C5[C@H](O)C[C@@]/34[H]

Molecular Formula

C40H55N3O6

Molecular Weight

673.88

References & Citations

[1]Zheng Liu, et al. Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway. Eur J Med Chem. 2023 Aug 1;259:115697.