Antitumor agent-116
Antitumor agent-116 (compound 6C) is an anti-tumor agent with anti-proliferative activities. Antitumor agent-11 induces cell apoptosis, and shows the binding affinity against the MELK receptor[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; MELK
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-116.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(N2C(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C2C5=CC(Br)=CC=C5O)C=C1)(NC6=NOC(C)=C6)=O
Molecular Formula
C31H23BrN4O4S
Molecular Weight
627.51
References & Citations
[1]Monalisa Mahapatra, et al. In-vitro anticancer evaluation of newly designed and characterized tri/tetra-substituted imidazole congeners- maternal embryonic leucine zipper kinase inhibitors: Molecular docking and MD simulation approaches. Int J Biol Macromol. 2023 Aug 1;249:126084.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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