JAK2-IN-9
JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM) . JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs) [1].
Product Specifications
CAS Number
[2568842-26-0]
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak2-in-9.html
Solubility
10 mM in DMSO
Smiles
C=CS(=O)(NCC1=CC=C(NC2=NC=C(C)C(C3=CN(C(C)C)N=C3)=N2)C=C1)=O
Molecular Formula
C20H24N6O2S
Molecular Weight
412.51
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155746/JAK2-IN-9-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155746/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2
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