JAK2-IN-9
Product Specifications
UNSPSC Description
JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM). JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs)[1].
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak2-in-9.html
Solubility
10 mM in DMSO
Smiles
C=CS(=O)(NCC1=CC=C(NC2=NC=C(C)C(C3=CN(C(C)C)N=C3)=N2)C=C1)=O
Molecular Weight
412.51
References & Citations
[1]Tian Y, et al Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors. ACS Med Chem Lett. 2023 Aug 1;14(8):1113-1121.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155746/JAK2-IN-9-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155746/
Clinical Information
No Development Reported
CAS Number
2568842-26-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6398739-01 0.1 mL
XIAP (X-linked Inhibitor of Apoptosis Protein, X-linked IAP, API3, Baculoviral IAP Repeat-containing Protein 4, BIRC4, E3 Ubiquitin-protein Ligase XIAP, FLJ26913, IAP-like Protein, ILP, hILP, ILP1, Inhibitor of Apoptosis Protein 3, IAP3, IAP-3, hIAP3, hIA
Ask
View Details MBS6398739-02 5x 0.1 mL
XIAP (X-linked Inhibitor of Apoptosis Protein, X-linked IAP, API3, Baculoviral IAP Repeat-containing Protein 4, BIRC4, E3 Ubiquitin-protein Ligase XIAP, FLJ26913, IAP-like Protein, ILP, hILP, ILP1, Inhibitor of Apoptosis Protein 3, IAP3, IAP-3, hIAP3, hIA
Ask
View Details 
![Rabbit Monoclonal Complement C6 Antibody (037) [Alexa Fluor 750]](https://cdn.genprice.uk/genprice/genprice5.png)
NBP2-90102AF750 0.1 mL
Rabbit Monoclonal Complement C6 Antibody (037) [Alexa Fluor 750]
Ask
View Details