JAK2-IN-9

JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM) . JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs) [1].

Product Specifications

CAS Number

[2568842-26-0]

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jak2-in-9.html

Solubility

10 mM in DMSO

Smiles

C=CS(=O)(NCC1=CC=C(NC2=NC=C(C)C(C3=CN(C(C)C)N=C3)=N2)C=C1)=O

Molecular Formula

C20H24N6O2S

Molecular Weight

412.51

References & Citations

[1]Tian Y, et al Discovery of N- (4- (Aminomethyl) phenyl) -5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors. ACS Med Chem Lett. 2023 Aug 1;14 (8) :1113-1121.