PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1].
Product Specifications
CAS Number
2765535-21-3
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-32.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC(COC2=C(C=CC(OCC3=C(C(C4=CC=CC=C4F)=CC=C3)Cl)=C2)CNCCO)=CN=C1
Molecular Formula
C29H25ClFN3O3
Molecular Weight
517.98
References & Citations
[1]Zhang H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4- (2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66 (15) :10579-10603.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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