ET receptor antagonist 3
ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist (IC50=0.26 nM), which can be used for research in pulmonary arterial hypertension (PAH). ET receptor antagonist 3 attenuates monocrotaline induced PAH in rat model[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/et-receptor-antagonist-3.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCC4N(C)CCC4)=C2OC5=CC=CC=C5OC)=O
Molecular Formula
C27H28N6O5S
Molecular Weight
548.61
References & Citations
[1]Panchal J, et al. Development of novel bosentan analogues as endothelin receptor antagonists for pulmonary arterial hypertension. Eur J Med Chem. 2023 Nov 5;259:115681.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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