ET receptor antagonist 1
ET receptor antagonist 1 (compound 16h) is an orally active ET receptor antagonist (IC50=0.18 nM), which can be used for research in pulmonary arterial hypertension (PAH). ET receptor antagonist 1 attenuates monocrotaline induced PAH in rat model[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/et-receptor-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
CC(CCOC(N=C1C2=NC=CC=N2)=C(C(NS(=O)(C)=O)=N1)OC3=CC=CC=C3OC)C
Molecular Formula
C21H25N5O5S
Molecular Weight
459.52
References & Citations
[1]Panchal J, et al. Development of novel bosentan analogues as endothelin receptor antagonists for pulmonary arterial hypertension. Eur J Med Chem. 2023 Nov 5;259:115681.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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