PI3K-IN-41

PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect[1].

Product Specifications

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-in-41.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(COC2=CC3=C(C=C(C(O3)=O)CN(S(C4=C(C=C(C=C4)F)F)(=O)=O)C5=C(N=CC(C6=CC7=C(N=CN=C7C(OC8CCOCC8)=C6)C)=C5)OC)C=C2)=C(C=C1OC)[N+]([O-])=O

Molecular Formula

C45H39F2N5O12S

Molecular Weight

911.88

References & Citations

[1]Tian H, et al. Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release. ACS Med Chem Lett. 2023 Jul 24;14 (8) :1100-1107.