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Sirt1/2-IN-4

Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity[1].

Product Specifications

CAS Number

2999646-13-6

UNSPSC

12352005

Target

Apoptosis; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt1-2-in-4.html

Solubility

10 mM in DMSO

Smiles

O=S(NC1=CC(SC2=NNC=N2)=C(C3=C1C=CC=C3)O)(C4=C(C)C(C)=C(C)C=C4)=O

Molecular Formula

C21H20N4O3S2

Molecular Weight

440.54

References & Citations

[1]Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63 (15) :4780-4790.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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