Sirt1/2-IN-2
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].
Product Specifications
CAS Number
[670267-73-9]
UNSPSC
12352005
Target
Apoptosis; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt1-2-in-2.html
Purity
90.0
Solubility
10 mM in DMSO
Smiles
O=S(NC1=CC(SC2=NN=CN2)=C(C3=C1C=CC=C3)O)(C4=CC=CC=C4)=O
Molecular Formula
C18H14N4O3S2
Molecular Weight
398.46
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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