Mtb-IN-4
Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM) . Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant[1].
Product Specifications
CAS Number
2306039-13-2
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mtb-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CSC2=C(C3CC3)C(C4=CC(C5=CC=C6C=CC=CC6=C5)=NO4)=CC(N21)=O)O
Molecular Formula
C24H18N2O4S
Molecular Weight
430.48
References & Citations
[1]Sarkar S, et al. Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant. J Med Chem. 2023 Aug 24;66 (16) :11056-11077.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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