Fac-[Re (CO) 3 (L3) (H2O) ][NO3]
Fac-[Re (CO) 3 (L3) (H2O) ][NO3] (compound 3), the rhenium (I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re (CO) 3 (L3) (H2O) ][NO3] is cytotoxic to prostate cancer cells with IC50=0.32 μM (PC-3 cells) . fac-[Re (CO) 3 (L3) (H2O) ][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re (CO) 3 (L3) (H2O) ][NO3] did not induce necrosis, apoptosis and autophagy[1].
Product Specifications
UNSPSC
12352005
Target
Paraptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fac-re-co-3-l3-h2o-no3.html
Solubility
10 mM in DMSO
Smiles
[OH2][Re+]1([N]2=CC=CC3=C2C4=C(C5=C3N=C(C6=CNC7=C6C=C(OC)C=C7)N5)C=CC=[N]41)([C]=O)([C]=O)[C]=O.[O-][N+]([O-])=O
Molecular Formula
C25H17N6O8Re
Molecular Weight
715.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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