Fac-[Re (CO) 3 (L6) (H2O) ][NO3]
Fac-[Re (CO) 3 (L6) (H2O) ][NO3] (compound 6), the rhenium (I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re (CO) 3 (L6) (H2O) ][NO3] is cytotoxic to prostate cancer cells, IC50=50 nM (PC-3 cells) . fac-[Re (CO) 3 (L6) (H2O) ][NO3] mainly accumulates in the nucleus, down-regulates ATP production in PC3 cells, and promotes apoptosis. However, fac-[Re (CO) 3 (L6) (H2O) ][NO3] did not induce necrosis, pyrodeath and autophagy[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fac-re-co-3-l6-h2o-no3.html
Solubility
10 mM in DMSO
Smiles
[OH2][Re+]1([N]2=CC=CC3=C2C4=C(C5=C3N=C(N5)C6=CC7=C(S6)C=CC=C7)C=CC=[N]41)([C]=O)([C]=O)[C]=O.[O-][N+]([O-])=O
Molecular Formula
C24H14N5O7ReS
Molecular Weight
702.67
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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