AChE-IN-34
Product Specifications
UNSPSC Description
AChE-IN-34 (compound 5l) is a potent and selective AChE inhibitor with an IC50 value of 3.98 µM with no significant inhibition against BChE. AChE-IN-34 inhibits AChE with a Ki of 0.044 μM in a mixed mode (Acetylthiocholine substrate; 0.1-1 mM)[1].
Target Antigen
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-34.html
Solubility
10 mM in DMSO
Smiles
NC1=C(C#N)C2(C3=C(NC2=O)C=CC([N+]([O-])=O)=C3)C([N+]([O-])=O)=C(NC4=CC=C(O)C=C4)NN1
Molecular Weight
450.36
References & Citations
[1]Hormoz Pourtaher, et al. The anti-Alzheimer potential of novel spiroindolin-1,2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents. Sci Rep. 2023 Jul 24;13(1):11952.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155713/AChE-IN-34-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155713/
Clinical Information
No Development Reported
Curated Selection
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