AChE-IN-34

AChE-IN-34 (compound 5l) is a potent and selective AChE inhibitor with an IC50 value of 3.98 µM with no significant inhibition against BChE. AChE-IN-34 inhibits AChE with a Ki of 0.044 μM in a mixed mode (Acetylthiocholine substrate; 0.1-1 mM) [1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-in-34.html

Solubility

10 mM in DMSO

Smiles

NC1=C(C#N)C2(C3=C(NC2=O)C=CC([N+]([O-])=O)=C3)C([N+]([O-])=O)=C(NC4=CC=C(O)C=C4)NN1

Molecular Formula

C19H14N8O6

Molecular Weight

450.36

References & Citations

[1]Hormoz Pourtaher, et al. The anti-Alzheimer potential of novel spiroindolin-1,2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents. Sci Rep. 2023 Jul 24;13 (1) :11952.