Antifungal agent 68
Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51) . There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51[1].
Product Specifications
CAS Number
2925307-53-3
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antifungal-agent-68.html
Solubility
10 mM in DMSO
Smiles
CCCC1=CC=C(OCC(OCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(OC)=C1
Molecular Formula
C23H27ClN2O3
Molecular Weight
414.93
References & Citations
[1]Campos Péret VA, et al. New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis. Eur J Med Chem. 2023 Aug 5;256:115436..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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