MOR agonist-3
MOR agonist-3 (Compound 84) is a D3R/MOR antagonist/partial agonist a (Ki 382 nM and 55.2 nM respectively). MOR agonist-3 has the potential to produce analgesic effects through MOR (μ-opioid receptor) partial agonists and to reduce opioid abuse through D3R antagonists. MOR agonist-3 can be used in the treatment of inflammation and neuropathic pain research[1].
Product Specifications
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mor-agonist-3.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN[C@H]3[C@H](C4=CC=CC=C4OC)C3
Molecular Formula
C28H32N2O2
Molecular Weight
428.57
References & Citations
[1]Bonifazi A, et al. Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. J Med Chem. 2023 Aug 10;66 (15) :10304-10341.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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