MOR agonist-3

MOR agonist-3 (Compound 84) is a D3R/MOR antagonist/partial agonist a (Ki 382 nM and 55.2 nM respectively) . MOR agonist-3 has the potential to produce analgesic effects through MOR (μ-opioid receptor) (HY-149337) partial agonists and to reduce opioid abuse through D3R antagonists. MOR agonist-3 can be used in the treatment of inflammation and neuropathic pain research[1].

Product Specifications

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mor-agonist-3.html

Solubility

10 mM in DMSO

Smiles

O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN[C@H]3[C@H](C4=CC=CC=C4OC)C3

Molecular Formula

C28H32N2O2

Molecular Weight

428.57

References & Citations

[1]Bonifazi A, et al. Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. J Med Chem. 2023 Aug 10;66 (15) :10304-10341.