MOR agonist-2

MOR agonist-2 (compound 46) is a antagonist of D3R and agonist of MOR (Ki: 7.26 nM and 564 nM, respectively) . MOR agonist-2 has the potential to produce analgesic effects through MOR partial agonism. MOR agonist-2 reduces opioid-misuse liability via D3R antagonism[1].

Product Specifications

CAS Number

2833692-02-5

UNSPSC

12352005

Target

Dopamine Receptor; Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mor-agonist-2.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(N(C)C)=O)C[C@H](O)C1)NCCCCN4CCN(C5=CC=CC(Cl)=C5Cl)CC4

Molecular Formula

C37H47Cl2N5O3

Molecular Weight

680.71

References & Citations

[1] Bonifazi A, et al. Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. J Med Chem. 2023 Aug 10;66 (15) :10304-10341.